Oncogene-mediated alterations in chromatin conformation
نویسندگان
چکیده
منابع مشابه
Oncogene-mediated alterations in chromatin conformation.
Emerging evidence suggests that chromatin adopts a nonrandom 3D topology and that the organization of genes into structural hubs and domains affects their transcriptional status. How chromatin conformation changes in diseases such as cancer is poorly understood. Moreover, how oncogenic transcription factors, which bind to thousands of sites across the genome, influence gene regulation by global...
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Chromatin conformation capture (3C) and related techniques have become well-established methods to examine which distal DNA sequences are spatially located close to a locus of interest. Hi-C is a new addition to the growing set of 3C-based techniques that has extended the approach to a genome-wide analysis of nuclear chromatin using high-throughput DNA sequencing to generate global interaction ...
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The centromere region of Saccharomyces cerevisiae chromosome III has been replaced by various DNA fragments from the centromere regions of yeast chromosomes III and XI. A 289-base pair centromere (CEN3) sequence can stabilize yeast chromosome III through mitosis and meiosis. The orientation of the centromeric fragments within chromosome III has no effect on the normal mitotic or meiotic behavio...
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Pluripotency, the ability of a cell to give rise to all of the cells of an organism, is a fascinating and mysterious characteristic of embryonic stem (ES) cells. Recent extensive molecular studies of mouse ES cells have revealed the roles played by transcription factor networks and epigenetic processes in the maintenance of ES cell pluripotency (Niwa 2007). However, no direct evidence to connec...
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Chromatin conformation plays a key role in regulating gene expression and controlling cell differentiation. However, the whole-genome chromatin conformation changes that occur during leukemia cell differentiation are poorly understood. Here, we characterized the changes in chromatin conformation, histone states, chromatin accessibility, and gene expression using an all-trans retinoic acid (ATRA...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2012
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1112570109